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Resistance of Phytohæmagglutinin-treated Lymphocytes to X-rays and Nitrogen Mustard

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Abstract

A PREVIOUS investigation has shown that phytohæmagglutinin can transform normal human lymphocytes into lymphoblastoid cells1. The normal lymphocyte is highly sensitive to nitrogen mustard (HN2) and to irradiation with small doses of X-rays2. We were, therefore, surprised to find in this work that the derived lymphoblastoid cells are resistant to these reagents.

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References

  1. Schrek, R., and Rabinowitz, Y., Proc. Soc. Exp. Biol. Med. (in the press).

  2. Schrek, R., Friedman, I. A., and Leithold, S. L., J. Nat. Cancer Inst., 20, 1037 (1958).

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  3. Schrek, R., Arch. Path., 66, 569 (1958).

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Authors and Affiliations

  1. Tumor Research Laboratory, Research and Surgical Services, Veterans Administration Hospital, Hines, Illinois

    ROBERT SCHREK & STEFAN STEFANI

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  1. ROBERT SCHREK
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  2. STEFAN STEFANI
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SCHREK, R., STEFANI, S. Resistance of Phytohæmagglutinin-treated Lymphocytes to X-rays and Nitrogen Mustard. Nature 200, 482–483 (1963). https://doi.org/10.1038/200482a0

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