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Establishment and Stability of Chimerism between Two Closely Related Lines of Mice

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Abstract

THE Medical Research Council Radiobiology Unit at Harwell recently developed a strain of CBA mice containing the T6 marker chromosomes3,4. They kindly sent a breeding unit to the Chester Beatty Research Institute. This communication concerns a short series of experiments involving descendants of these (CBA/T6T6) mice and the Chester Beatty CBA. The purpose of the experiments was, first, to define the immunological relationship between the strains ; secondly, to describe the conditions under which chimerism could be established between them; thirdly, to investigate the extent and stability of this chimeric state.

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Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, London, S.W.3

    A. J. S. DAVIES, SHEILA M. A. DOAK & ELIZABETH LEUCHARS

Authors
  1. A. J. S. DAVIES
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  2. SHEILA M. A. DOAK
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  3. ELIZABETH LEUCHARS
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DAVIES, A., DOAK, S. & LEUCHARS, E. Establishment and Stability of Chimerism between Two Closely Related Lines of Mice. Nature 200, 1222–1223 (1963). https://doi.org/10.1038/2001222a0

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