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Responses of Germ-free Mice to Friend Virus

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Abstract

CONSIDERABLE interest has developed in the germ-free animal as an assay system for potential oncogenic viruses. Theoretically it should provide a more uniform test system than the conventional animal with its unpredictable microflora which may influence unpredictably the response to the agent being studied. For this reason we undertook a comparative study of Friend virus infection in germ-free and conventional mice of the same strain. This communication concerns the results of this investigation.

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Authors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, and State University of New York at Buffalo, Buffalo, 3, New York

    EDWIN A. MIRAND & JAMES T. GRACE JUN.

Authors
  1. EDWIN A. MIRAND
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  2. JAMES T. GRACE JUN.
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MIRAND, E., GRACE, J. Responses of Germ-free Mice to Friend Virus. Nature 200, 92–93 (1963). https://doi.org/10.1038/200092a0

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