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Demonstration of a Hæmolytically Active II S Component of Rabbit, Guinea Pig and Human Serum by means of Antigen–Antibody Precipitates

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Abstract

Taranta, Weiss and Franklin1 and Müller-Eberhard and Kunkel2 independently described a heat-labile substance in normal human serum which was capable of precipitating soluble aggregates of γ-globulin. The latter authors2 isolated the factor from aggregated γ-globulin precipitated with normal human serum in the presence of ethylenediamine tetraacetic acid (EDTA). They showed that it was a euglobulin with an S020w of 11 and further demonstrated that it constituted a component of hæmolytic complement distinct from the known components of the human system. They termed it the “11 S component”. It will be shown that this same component is also present in guinea pig and rabbit serum and that it can be removed from these sera with immune precipitates in the presence of EDTA.

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References

  1. Taranta, A., Weiss, H. S., and Franklin, E. C., Nature, 189, 239 (1961).

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  2. Müller-Eberhard, H. J., and Kunkel, H. G., Proc. Soc. Exp. Biol. Med., 106, 291 (1961).

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  3. Kent, J. F., Bukantz, S. C., and Rein, C. R., J. Immunol., 53, 37 (1946).

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  1. Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, 12, D.C.

    J. F. BARBARO

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  1. J. F. BARBARO
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BARBARO, J. Demonstration of a Hæmolytically Active II S Component of Rabbit, Guinea Pig and Human Serum by means of Antigen–Antibody Precipitates. Nature 199, 819–820 (1963). https://doi.org/10.1038/199819a0

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