Abstract
IT has previously1 been shown that two brownish-yellow pigments could be isolated from the incubation mixture when a strain of Aerobacter aerogenes is grown in the presence of vitamin B12 in a glucose-salt medium. The pigment (pigment I) present in greatest quantity was shown to be derived from vitamin B12. It differed from vitamin B12 in its absorption spectrum and its electrophoretic and chromatographic properties. It was stable to air and light and was not as the cobamide coenzymes converted to aquocobalamin by the addition of potassium cyanide.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Helegeland, K., Jonsen, J., and Laland, S., Biochem. J., 81, 260 (1961).
Ford, J. E., Brit. J. Nutrit., 7, 299 (1953).
Killander, A., Acta Chem. Scand., 9, 1045 (1955).
Ungley, C. C., Vitamins and Hormones, 13, 173 (1955).
Coates, M. E., and Kon, S. K., Vitamin B12 and Intrinsic Factor, 72 (Ferdinand Enke Verlag, Stuttgart, 1957). Blumberger, K., Petrides, P., and Bernhauer, K., ibid., 82.
Hill, J. A., Pratt, J. M., and Williams, R. J. P., J. Theor. Biol., 3, 423 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HELGELAND, K., JONSEN, J., LALAND, S. et al. Biological Activity of a Brownish-Yellow Pigment produced from Vitamin B12 by Aerobacter aerogenes. Nature 199, 604–605 (1963). https://doi.org/10.1038/199604a0
Issue Date:
DOI: https://doi.org/10.1038/199604a0
- Springer Nature Limited
This article is cited by
-
Coding recognition of the dose–effect interdependence of small biomolecules encrypted on paired chromatographic-based microassay arrays
Analytical and Bioanalytical Chemistry (2022)