Skip to main content
SpringerLink
Log in

Biomicroscopic Observations on Vasocon-strictive and Thrombogenic Effects produced by Long-chain Saturated Fatty Acids within the Vasculature of the Wing of an Unanæsthetized Bat

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

POOLE1 reported in 1955 that when certain fatty acids in low concentration are added to plasma the clotting time is shortened. In 1959 he2 modified Chandler's3 system to make and to study artificial thrombi. In 1961, with Connor4, he showed that when straight-chain saturated fatty acids with 16 or more carbon atoms were added to mixtures of blood in Chandler's system thrombus formation was accelerated and the thrombi so formed larger. Short -chain fatty acids, C6 and C7, had no activity and unsat-urated acids were inactive, or very nearly so.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Poole, J. C. F., Brit. J. Exp. Path., 36, 248 (1955).

    PubMed  CAS  Google Scholar 

  2. Poole, J. C. F., Quart. J. Exp. Physiol., 44, 377 (1959).

    Article  CAS  Google Scholar 

  3. Chandler, A. B., Lab. Invest., 7, 110 (1958).

    PubMed  CAS  Google Scholar 

  4. Connor, W. G., and Poole, J. C. F., Quart. J. Exp. Phys., 46, 1 (1961).

    Article  CAS  Google Scholar 

  5. Connor, W. G., Hoak, J. C., and Warner, E. D., Fed. Proc., 21, 60 (1962) (abstract).

    Google Scholar 

  6. Soloff, L. A., and Day, H. J., Clin. Proc. (to be published) (abstract).

  7. Nicoll, P. A., and Webb, R. L., Ann. N.Y. Acad. Sci., 46, 697 (1946).

    Article  ADS  Google Scholar 

  8. Duguid, J. B., J. Path. Bact., 58, 207 (1946).

    Article  CAS  Google Scholar 

  9. Anitschow, N., Chalatow, S., Centrablf. allg. Path. Path. Anat., 24, 1 (1913).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Temple University Medical Center, Philadelphia

    LOUIS A. SOLOFF & MARY P. WIEDEMAN

Authors
  1. LOUIS A. SOLOFF
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MARY P. WIEDEMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SOLOFF, L., WIEDEMAN, M. Biomicroscopic Observations on Vasocon-strictive and Thrombogenic Effects produced by Long-chain Saturated Fatty Acids within the Vasculature of the Wing of an Unanæsthetized Bat. Nature 199, 495–496 (1963). https://doi.org/10.1038/199495a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/199495a0

  • Springer Nature Limited

This article is cited by

Search

Navigation