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Stimulation by Rat Liver Ribonucleic Acid of Incorporation of Amino-acid into Rat Liver Ribosomes

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Abstract

THE discovery1 that ribonucleic acid (RNA) and synthetic polyribonucleotides stimulated the incorporation of amino -acids into protein-like material in cell-free system from E. coli has been followed by many reports2–6 of similar findings with systems from the same and other cells. Rat liver RNA was shown5 to stimulate amino-acid incorporation when added to an E. coli system and rat liver RNA and polyuridylic acid caused increased incorporation of phenylalanine in a rat-liver microsomal system6. We wish to report that polyuridylic acid and rat liver RNA stimulate incorporation of amino-acid with rat liver ribo-somes.

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge,

    A. KORNER & A. J. MUNRO

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  1. A. KORNER
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  2. A. J. MUNRO
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KORNER, A., MUNRO, A. Stimulation by Rat Liver Ribonucleic Acid of Incorporation of Amino-acid into Rat Liver Ribosomes. Nature 199, 489–490 (1963). https://doi.org/10.1038/199489a0

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