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Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine

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Abstract

Bowman and Rand have suggested that the mechanism by which the triethyl analogue of choline causes failure of neuromuscular transmission is by interfering with synthesis of acetylcholine in the nerve endings1. If so. triethylcholine may be like HC-3 (hemicholinium), wilich has been found to inhibit the synthesis of acetylcholine by organized nerve tissue2,3.

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References

  1. Bowman, W. C., and Rand, M. J., Brit. J. Pharmacol., 17, 176 (1961).

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  2. MacIntosh, F. C., Birks, R. I., and Sastry, P. B., Nature, 178, 1181 (1956).

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  3. Gardiner, J. E., Biochem. J., 81, 297 (1961).

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  4. Hebb, C. O., Handbook of Experimental Pharmacology, Supp., 15, edit. by Koelle, G. B. (Springer-Verlag, Berlin, 1963).

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  5. Hebb, C. O., and Smallman, B. N., J. Physiol., 134, 385 (1956).

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Authors and Affiliations

  1. Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge

    G. BULL

  2. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, W.C.1

    B. A. HEMSWORTH

Authors
  1. G. BULL
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  2. B. A. HEMSWORTH
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BULL, G., HEMSWORTH, B. Inhibition of Biological Synthesis of Acetylcholine by Triethylcholine. Nature 199, 487–488 (1963). https://doi.org/10.1038/199487b0

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