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Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits

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Abstract

THE characteristic histological abnormalities of toxæmia of pregnancy (pre-eclampsia) are found in glomeruli and consist mainly of endothelial swelling1. Electron microscopic studies of renal biopsies have confirmed that the main change is marked swelling of endothelial and inter-capillary cells, and have shown in addition the frequent occurrence of dark, granular material deposited between the swollen endothelial cells or along the basement membranes2,3.

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Author notes

  1. P. VASSALLI

    Present address: Department of Pathology, New York University School of Medicine, New York

Authors and Affiliations

  1. Departments of Histology and Pathology, University of Geneva School of Medicine, Switzerland

    P. VASSALLI, G. SIMON & C. ROUILLER

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  1. P. VASSALLI
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  2. G. SIMON
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  3. C. ROUILLER
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VASSALLI, P., SIMON, G. & ROUILLER, C. Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits. Nature 199, 1105–1106 (1963). https://doi.org/10.1038/1991105a0

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