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Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A ’

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Abstract

THE demonstration that 6-mercaptopurine (6-MP) is capable of inhibiting the immune response1,2 has aroused much interest and optimism concerning the therapeutic possibilities for organ transplantation and ‘auto-immune’ diseases. Extension of these studies has shown that immunological tolerance can be obtained by administration of 6-MP during the primary exposure to an antigen3. Although initial attempts to modify the secondary response to the antigen were unsuccessful4, a quantitative rather than qualitative effect seems to have been responsible, since proper timing and vigorous treatment with both antigen and drug will achieve complete suppression of specific antibody production in previously immunized animals5,6.

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Authors and Affiliations

  1. Yale School of Medicine, New Haven, Connecticut

    STANLEY ROSENBERG & PAUL CALABRESI

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  1. STANLEY ROSENBERG
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  2. PAUL CALABRESI
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ROSENBERG, S., CALABRESI, P. Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A ’. Nature 199, 1101–1102 (1963). https://doi.org/10.1038/1991101a0

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