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Enzyme Dissolution of the Nucleus Pulposus

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Abstract

THOMAS showed the surprising susceptibility of cartilage to the action of papain when he produced collapse of the ears of young rabbits by injecting the enzyme intravenously1,2. All cartilaginous tissue of the body was affected; the epiphyseal cartilages appeared to be particularly sensitive. Larger doses caused softening of tracheal cartilage to such a degree that some animals died from respiratory obstruction. The changes occurring in cartilage after intravenous papain were the result of a widespread breakdown of chondromucoprotein.

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References

  1. Thomas, L., J. Exp. Med., 104, 245 (1958).

    Article  Google Scholar 

  2. McCluskey, R. T., and Thomas, L., J. Exp. Med., 108, 371 (1958).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Di Ferrante, N., J. Biol. Chem., 220, 303 (1956).

    PubMed  CAS  Google Scholar 

  4. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  5. Riser, W. H., North Amer. Vet., 27, 633 (1946).

    CAS  Google Scholar 

  6. Hansen, H. J., Acta Ortho. Scand., Supp. 11 (1952).

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Authors and Affiliations

  1. Sherman Hospital, Elgin, Illinois

    LYMAN SMITH

  2. Department of Orthopedic Surgery, Northwestern University Medical School, Chicago

    LYMAN SMITH

  3. Pharmacology Section, Baxter Laboratories, Inc., Morton Grove, Illinois

    P. J. GARVIN & R. M. GESLER

  4. Department of Pathology, Northwestern University Medical School, Chicago

    R. B. JENNINGS

Authors
  1. LYMAN SMITH
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  2. P. J. GARVIN
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  3. R. M. GESLER
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  4. R. B. JENNINGS
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SMITH, L., GARVIN, P., GESLER, R. et al. Enzyme Dissolution of the Nucleus Pulposus. Nature 198, 1311–1312 (1963). https://doi.org/10.1038/1981311a0

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  • DOI: https://doi.org/10.1038/1981311a0

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