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Histamine-liberating Effect of Magnesium Deficiency in the Rat

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Abstract

DIETARY magnesium deficiency in the rat gives rise, after a few days, to a characteristic peripheral vasodilation with erythæma and œdema1. This change lasts for about a week, regresses and then re-appears later on. The signs of magnesium deficiency have been tentatively ascribed to a secondary vitamin B deficiency2 and have also been compared to human neurodermatitis3. However, it was shown recently that magnesium deficiency induces a decrease in the number of subcutaneous mast cells4, as well as an impairment in mast cell regeneration5. These observations are indicative of a change in histamine distribution that could be ascertained by measuring plasma and urinary histamine.

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Authors and Affiliations

  1. Département de Pharmacologie, Faculté de Médecine, Université de Montréal,

    P. BOIS, A. GASCON & A. BEAULNES

Authors
  1. P. BOIS
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  2. A. GASCON
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  3. A. BEAULNES
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BOIS, P., GASCON, A. & BEAULNES, A. Histamine-liberating Effect of Magnesium Deficiency in the Rat. Nature 197, 501–502 (1963). https://doi.org/10.1038/197501a0

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