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Synthesis of Hæm in Normal and Leukæmic Leucocytes

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Abstract

RECENT investigations suggest that the formation of hæm from iron and protoporphyrin is enzymatic in avian erythrocytes1–4, rat liver5,6 and canine muscle7. The hæmoproteins, such as catalase, peroxidase and the cytochromes, exist in leucocytes8; however, the origin of hæm for these proteins is not apparent. The present study concerns the formation of hæm in a leucocyte system.

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Author notes

  1. THOMAS R. WALTERS: Postdoctoral Research Fellow, National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service.

  2. HERBERT C. SCHWARTZ: John and Mary R. Markle Scholar in Medical Science.

Authors and Affiliations

  1. Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California

    THOMAS R. WALTERS, T. JOHN GRIBBLE & HERBERT C. SCHWARTZ

Authors
  1. THOMAS R. WALTERS
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  2. T. JOHN GRIBBLE
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  3. HERBERT C. SCHWARTZ
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WALTERS, T., GRIBBLE, T. & SCHWARTZ, H. Synthesis of Hæm in Normal and Leukæmic Leucocytes. Nature 197, 1213–1214 (1963). https://doi.org/10.1038/1971213a0

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