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Stress hormones and brain aging: adding injury to insult?

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Abstract

Glucocorticoids are known to promote the death of neurons in a variety of experimental systems. A new study suggests that they may also contribute to hippocampal atrophy during normal human aging.

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Figure 1: The glucocorticoid hypothesis of cognitive decline in aging.
Figure 2

References

  1. Coleman, P. & Flood, D. Neurobiol. Aging 8, 521–545 (1987)

    Article  CAS  Google Scholar 

  2. DeToledo-Morrell, L., Geinisman, Y. & Morrell, F. Neurobiol. Aging 9, 581– 590 (1988)

    Article  CAS  Google Scholar 

  3. Barnes, C.A. Trends. Neurosci. 17, 8–13 (1994 )

    Article  Google Scholar 

  4. Squire, L.R. Psychol. Rev. 99, 195–231 (1992)

    Article  CAS  Google Scholar 

  5. McEwen, B.S., De Kloet, E.R. & Rostene, W. Physiol. Rev. 66, 1121– 1188 (1986)

    Article  CAS  Google Scholar 

  6. Landfield, P., Waymire, J. & Lynch, G. Science 202, 1098–1102 (1978)

    Article  CAS  Google Scholar 

  7. Landfield, P., Baskin, R.K. & Pitler, T.A. Science 214, 581– 583 (1981)

    Article  CAS  Google Scholar 

  8. Meaney, M.J., Aitken, D.H., Van Berkel, C., Bhatnagar, S. & Sapolsky, R.M. Science 239, 766– 768 (1988)

    Article  CAS  Google Scholar 

  9. Landfield, P.W. & Eldridge, J.C. Neurobiol. Aging 15, 579–588 (1994)

    Article  CAS  Google Scholar 

  10. Sapolsky, R.M. Ann. NY Acad. Sci. 746, 294–304 (1994)

    Article  CAS  Google Scholar 

  11. Reagan, L.P. & McEwen, B.S. J. Chem. Neuroanat. 13, 149–167 (1997)

    Article  CAS  Google Scholar 

  12. Joels, M. & De Kloet, E.R. Prog. Neurobiol. 43, 1–36 (1994)

    Article  CAS  Google Scholar 

  13. Maguire, E.A., Frackowiak, R.S.J. & Frith, C.D. J. Neurosci. 17, 7103– 7110 (1997)

    Article  CAS  Google Scholar 

  14. Gallagher, M. et al. Science 274, 484–485 (1996)

    Article  CAS  Google Scholar 

  15. McConkey, D.J. & Orrenius, S. Biochem. Biophys. Res. Comm. 239, 357–366 (1997)

    Article  CAS  Google Scholar 

  16. Landfield, P.W., Thibault, O., Mazzanti, M.L., Porter, N.M. & Kerr, D.S. J. Neurobiol. 23, 1247–1260 (1992)

    Article  CAS  Google Scholar 

  17. Simpkins, J.W., Singh, M. & Bishop, J. Neurobiol. Aging 15, S195– 197 (1994)

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, MS-307, University of Kentucky, Lexington, 40536-0084, Kentucky, USA

    Nada Porter & Philip W. Landfield

  2. Nada Porter

Authors
  1. Nada Porter
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  2. Philip W. Landfield
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Porter, N., Landfield, P. Stress hormones and brain aging: adding injury to insult?. Nat Neurosci 1, 3–4 (1998). https://doi.org/10.1038/196

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