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Mechanism of X-ray Inhibition of the Sodium Pump in Human Erythrocytes: Adenotriphosphatase Activity of Stromata

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Abstract

PREVIOUS results have shown that X-irradiation of human erythrocytes decreases the active efflux of sodium (sodium pump)1. However, 890 rads and 4,450 rads, which are effective in inducing a 45 and 73 per cent decrease of the active sodium efflux, respectively, do not inhibit glycolysis nor produce any effect on concentration of adenotriphosphate in red blood cells2. The lack of inhibition of the cellular system furnishing energy to the ion pump led us to investigate the biochemical mechanism in the membrane which underlies the active movement of sodium across the membrane.

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References

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Author notes

  1. FRANCESCO BRESCIANI

    Present address: Department of Biology, Brookhaven National Laboratory, Upton, Long Island, New York

Authors and Affiliations

  1. Institute of General Pathology, University of Naples,

    FRANCESCO BRESCIANI, FERDINANDO AURICCHIO & CESARE FIORE

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  1. FRANCESCO BRESCIANI
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  2. FERDINANDO AURICCHIO
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  3. CESARE FIORE
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BRESCIANI, F., AURICCHIO, F. & FIORE, C. Mechanism of X-ray Inhibition of the Sodium Pump in Human Erythrocytes: Adenotriphosphatase Activity of Stromata. Nature 196, 186–187 (1962). https://doi.org/10.1038/196186a0

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