Abstract
THE affinity of tetracycline antibiotics for divalent metal cations1–2 led to the hypothesis that the biological effect of these antibiotics is dependent on the presence of these cations and is brought about by complexing with macromolecules through metal ions. The formation of metal bridges was proved, for example, in binding of tetracyclines on serum albumin or deoxyribonucleic acid3. Metal-mediated binding of tetracyclines to macromolecules or cells assumes the presence of specific receptors, binding the metal cation.
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VINTER, V. Binding of Chlortetracycline on the Sporulating Cells of Bacilli and the Atypical Development of Spores. Nature 196, 1336–1337 (1962). https://doi.org/10.1038/1961336a0
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DOI: https://doi.org/10.1038/1961336a0
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