Abstract
Von Studnitz1, Greenberg and Gardner2, and Voorhess and Gardner3 have reported marked elevations in the urinary excretion of 3-O-methylated metabolites in the urine of patients with neural tumours. It is possible that these urinary products arise mainly from O-methylation of their precursors in the liver. However, the fact that some of these patients have a normal blood pressure in the presence of a large endogenous production of norepinephrine suggested to us that metabolism of the norepinephrine may occur within the tumour.
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References
von Studnitz, W., Scand. J. Clin. Lab. Invest., 12, Supp. 48 (1958).
Greenberg, R. E., and Gardner, L. I., J. Clin. Invest., 39, 1729 (1960).
Voorhess, M. L., and Gardner, L. I., J. Clin. Endocrinol. Metab., 21, 321 (1961).
Axelrod, J., Albers, R. W., and Clemente, C. D., J. Neurochem., 5, 68 (1959).
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LABROSSE, E., KARON, M. Catechol-O-Methyltransferase Activity in Neuroblastoma Tumour. Nature 196, 1222–1223 (1962). https://doi.org/10.1038/1961222a0
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DOI: https://doi.org/10.1038/1961222a0
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