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Influence of Actinomycins on the Content of 17-Hydroxycorticosteroids in Guinea Pig Plasma

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Abstract

FOR some time we have been examining effects of the actinomycins in animals. For this purpose we used a pure crystalline preparation, aurantin, which contained fractions A1, A2, A3, identical respectively to C3, C2 and C1 fraction of the actinomycin C 1,2. The difference between the preparations seems to be only in quantitative proportions of the aforementioned fractions2,3. There are indirect indications that the antibiotics of this group stimulate the function of the adrenal cortex; but there are no published results testifying to an increased concentration of corticosteroids in blood caused by the influence of actinomycins. The report here gives the results obtained in an investigation of this problem.

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References

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Authors and Affiliations

  1. N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the U.S.S.R., Moscow

    J. PLANELLES, N. OZERETSKOVSKY & O. DJEKSENBAEV

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  1. J. PLANELLES
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  2. N. OZERETSKOVSKY
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  3. O. DJEKSENBAEV
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PLANELLES, J., OZERETSKOVSKY, N. & DJEKSENBAEV, O. Influence of Actinomycins on the Content of 17-Hydroxycorticosteroids in Guinea Pig Plasma. Nature 195, 713–714 (1962). https://doi.org/10.1038/195713a0

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