Skip to main content
Log in

Conditions influencing the Stability of Human Antihæmophilic Factor

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE lability of human antihæmophilic factor in both plasma and concentrates is a major hazard during purification, even when the reaction of solutions is maintained within the rather restricted optimum range of stability, which we find to be pH 7.1–7.2, and when preparative procedures are conducted at temperatures close to 0°.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Cohn, E. J., Strong, L. E., Hughes, W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 549 (1946).

    Article  Google Scholar 

  2. Kekwick, R. A., Mackay, M. E., Nance, M. H., and Record, B. R., Biochem. J., 60, 671 (1955).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kekwick, R. A., and Wolf, P., Lancet, i, 647 (1957).

  4. Wagner, R. H., Brinkhous, K. M., and Penick, G. D., in Hæmophilia and other Hæmorrhagic States, edit. by Brinkhous, K. M. (Univ. N. Carolina Press, Chapel Hill, N. C.).

  5. Alkjaersig, N., Fletcher, A. P., and Sherry, S., J. Biol. Chem., 234, 832 (1959).

    CAS  PubMed  Google Scholar 

  6. Pool, J. G., and Robinson, J., Brit. J. Hæmat., 5, 17 (1959).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

KEKWICK, R., WALTON, P. Conditions influencing the Stability of Human Antihæmophilic Factor. Nature 194, 878–879 (1962). https://doi.org/10.1038/194878a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/194878a0

  • Springer Nature Limited

This article is cited by

Navigation