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Blockade of Neuromuscular Transmission by Zinc

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Abstract

THE role of zinc in processes of biological interest has commanded increasing attention in recent years. Its participation as either an incidental or essentially specific component in various enzymatic reactions has been stressed by Vallee1,2. Edman has discussed in detail the action of zinc in causing relaxation of contracted glycerinated muscle fibres3–7, and on the basis of his results, he has developed a hypothesis of the mechanochemistry of the contraction–relaxation cycle of living muscle in which zinc (normally present in living fibres at about the same concentration as calcium) plays a critical part8.

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Authors and Affiliations

  1. Institute for Muscle Disease, New York

    ALEXANDER SANDOW & SAUL M. BIEN

Authors
  1. ALEXANDER SANDOW
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  2. SAUL M. BIEN
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SANDOW, A., BIEN, S. Blockade of Neuromuscular Transmission by Zinc. Nature 193, 689–690 (1962). https://doi.org/10.1038/193689a0

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