Abstract
PUBLISHED reports1,2 have indicated that fluid and salt transport across the isolated small intestine is very low in the absence of an external supply of substrate. Chemical measurements of net transport have shown that, of the many substrates tested, only glucose is able to support optimal absorption1. With such measurements, the tissue must be allowed to equilibrate for 20–30 min. before sufficient fluid or salt has been transported to allow accurate chemical measurements. Thus a considerable uncertainty exists as to how rapidly the absorptive process changes when glucose is added to or removed from the bathing media. A clarification of this point would indicate the extent to which utilizable energy is stored in the tissue.
Similar content being viewed by others
References
Smyth, D. H., and Taylor, C. B., J. Physiol., 136, 632 (1957).
Lifson, N., and Parsons, D. S., Proc. Soc. Exp. Biol. Med., 95, 532 (1957).
Ussing, H. H., Fourth International Congress of Biochemistry, Symp. 3, 1 (Pergamon Press, London, 1959).
Curran, P. F., and Soloman, A. K., J. Gen. Physiol., 41, 143 (1957).
Clarkson, T. W., and Rothstein, A., Amer. J. Physiol., 199, 12 (1960).
Chinard, F. P., Taylor, W. R., Nolan, M. F., and Enns, T., Amer. J. Physiol., 196, 535 (1959).
Leaf, A., and Renshaw, A., Biochem. J., 65, 90 (1957).
Leaf, A., Page, L. B., and Anderson, J., J. Biol. Chem., 234, 1625 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLARKSON, T., CROSS, A. & TOOLE, S. Dependence on Substrate of the Electrical Potential across the Isolated Gut. Nature 191, 501–502 (1961). https://doi.org/10.1038/191501a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/191501a0
- Springer Nature Limited
This article is cited by
-
Electrical properties and glucose transfer in the goldfish intestine
Experientia (1964)