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Inhibition of Chemi-luminescence of Luminol by means of Oximes

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Abstract

IT is known that oximes with widely different chemical structures are effective reactivators of cholinesterase inhibited by organo-phosphorous compounds (esters of phosphoric or thiophoric acid, insecticides, nerve gases)1. The mechanism of this reaction is considered to be due to the chemical interaction of oximes with the free or bound ester of phosphoric acid, which is hydrolysed by the oxime2, and is not available for the inhibition of the cholinesterase. It is known that organo-phosphorous compounds catalyse the luminol reaction causing an intensive chemi-luminescence of luminol (3-amino-phthalylhydrazide) in alkaline medium in the presence of sodium perborate as oxygen donor3.

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References

  1. Davies, D. R., and Greeb, A. L., Brit. J. Industr. Med., 16, 128 (1959). Holmstedt, B., Pharmacol. Rev., 11, 567 (1959).

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  2. Green, A. L., and Sasille, B., J. Chem. Soc., 3887 (1956).

  3. Goldenson, J., Anal. Chem., 29, 877 (1957).

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Authors and Affiliations

  1. Yugoslav Academy of Sciences and Arts, Institute for Medical Research (incorporating the Institute of Industrial Hygiene), Zagreb

    K. WEBER, J. MATKOVIĆ & D. FLEŠ

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  1. K. WEBER
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  2. J. MATKOVIĆ
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  3. D. FLEŠ
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WEBER, K., MATKOVIĆ, J. & FLEŠ, D. Inhibition of Chemi-luminescence of Luminol by means of Oximes. Nature 191, 177–178 (1961). https://doi.org/10.1038/191177a0

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