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Polymorphism of α1-Acid Glycoprotein

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Abstract

α1-ACID glycoprotein1,2, a human plasma protein of low molecular weight, has been prepared in a state of extremely high purity as evidenced by electrophoresis and ultracentrifugation over a pH range of 1–12 and by terminal amino-acid and immuno-chemical analyses. Starch-gel electrophoresis of this blood constituent at pH 8.5 according to Smithies3,4 also demonstrated homogeneity. α1-Acid glycoprotein is further distinguished by the unusually low isoelectric point reported to be at pH 2.7 and the high carbohydrate content accounting for 40 per cent and consisting of sialic acid, galactose, mannose, fucose and N-acetyl-glucosamine.

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Author notes

  1. K. SCHMID: Established Investigator of the Helen Hay Whitney Foundation.

Authors and Affiliations

  1. Department of Medicine, Harvard Medical School and the Massachusetts General Hospital (Robert W. Lovett Memorial Unit for the Study of Crippling Disease), Boston, Mass.

    K. SCHMID & J. P. BINETTE

Authors
  1. K. SCHMID
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  2. J. P. BINETTE
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SCHMID, K., BINETTE, J. Polymorphism of α1-Acid Glycoprotein. Nature 190, 630–631 (1961). https://doi.org/10.1038/190630a0

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