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Micellar Solubilization of Fatty Acids and Monoglycerides by Bile Salt Solutions

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Abstract

BILE salts were recognized as detergents some years ago1, but few investigations have been done on their detergent properties under physiological conditions. Aqueous solutions of detergents are known to form molecular aggregates called micelles2. These form above a critical micellar concentration (CMC) and can solubilize water-insoluble materials. Using synthetically prepared3, chromatographically pure4 bile salts, I have investigated the micellar solubilization of pure fatty acids and monoglycerides in bile salt solutions, under conditions simulating those present in human small intestinal content during fat absorption5.

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Authors and Affiliations

  1. Department of Physiological Chemistry, University of Lund,

    ALAN F. HOFMANN

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  1. ALAN F. HOFMANN
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HOFMANN, A. Micellar Solubilization of Fatty Acids and Monoglycerides by Bile Salt Solutions. Nature 190, 1106–1107 (1961). https://doi.org/10.1038/1901106a0

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