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Muscarinic Receptors

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Abstract

THE ( + )-isomers of acetyl-α- and acetyl-β-methyl-choline are respectively about 10 and 250 times more active as muscarinics than their corresponding enantiomorphs (Table 1). We have recently established the configuration of these ( + )-isomers as I and II1,2; their configurational identity with ( + )-muscarine (III) 3 about C5 is indicated in Fig. 1.

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Authors and Affiliations

  1. Chelsea College of Science and Technology, Manresa Road, London, S.W.3

    A. H. BECKETT, N. J. HARPER, J. W. CLITHEROW & E. LESSER

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  1. A. H. BECKETT
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  2. N. J. HARPER
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  3. J. W. CLITHEROW
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  4. E. LESSER
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BECKETT, A., HARPER, N., CLITHEROW, J. et al. Muscarinic Receptors. Nature 189, 671–673 (1961). https://doi.org/10.1038/189671b0

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