Abstract
SEVERAL substances, which affect brain metabolism, act upon the γ-aminobutyric acid-level in that organ1. Insulin-induced hypoglycæmia brings about a drop in the γ-aminobutyric acid-level, probably as a result of decreased glutamic acid concentration. The administration of some substances, known to inhibit glutamic acid decarboxylase, leads also to a drop in the level of γ-aminobutyric acid in the brain. Thus, semicarbazide, an inhibitor combining with the aldehyde group of pyridoxalphosphate, reduces the γ-aminobutyric acid-level in the brain by approximately 30 per cent2 ; in a similar way, 2-methyl-4-amino-5-oxymethylpyrimidine brings about a drop3. After the ethanol ingestion, however, the level of γ-aminobutyric acid content in the brain was found to be increased4.
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References
Cravioto, R. O., Massieu, G., and Izquierdo, J., Proc. Soc. Exp. Biol. Med., 78, 856 (1951).
Wiliam, K. F., and Bain, J. A., J. Pharmacol., 119, 255 (1957).
Rindi, G., and Ferrari, G., Nature, 183, 608 (1959).
Häkkinen, H. M., and Kulonen, E., Nature, 184, 726 (1959).
Wingo, W. J., and Awapara, J., J. Biol. Chem., 187, 267 (1950).
Turský, T., and Bielik, E., Bratisl. Lekár. Listy, 36, 404 (1956).
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TURSKÝ, T. Effect of Potassium Cyanide Poisoning on the γ-Aminobutyric Acid-Level in the Brain. Nature 187, 322–323 (1960). https://doi.org/10.1038/187322a0
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DOI: https://doi.org/10.1038/187322a0
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