Skip to main content
SpringerLink
Log in

Role of C′4 in the Antiglobulin Reaction

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

WHEN human red cells are incubated with fresh serum containing a complement-binding blood-group antibody, they become agglutinable by an anti-‘non-γ’ globulin serum, that is, a serum reacting with human globulins other than γ-globulin1–3. In such cases the antiglobulin serum reacts with complement (C′) rather than with the blood-group antibody4.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Chapter © 2016

References

  1. Dacie, J. V., Lancet, ii, 954 (1951).

  2. Mollison, P. L., and Cutbush, Marie, Lancet, i, 1290 (1955).

  3. Cutbush, Marie, Crawford, Hal, and Mollison, P. L., Brit. J. Hæmatol., 1, 410 (1955).

    Article  CAS  Google Scholar 

  4. Dacie, J. V., Crookston, J. H., and Christenson, W. N., Brit. J. Hæmatol., 3, 77 (1957).

    Article  CAS  Google Scholar 

  5. Mayer, M. M., and Levine, L., J. Immunol., 72, 516 (1954).

    CAS  PubMed  Google Scholar 

  6. Levine, L., Mayer, M., and Rapp, H. J., J. Immunol., 73, 435 (1954).

    CAS  Google Scholar 

  7. Coombs, A. M., and Coombs, R. R. A., J. Hygiene, 51, 509 (1953).

    Article  CAS  Google Scholar 

  8. Gandini, E., “Bibliotheca Haematol.”, Fasc. 10 (1959).

    Google Scholar 

  9. Pillemer, L., Ecker, E. E., Oncley, J. L., and Cohn, E. J., J. Exp. Med., 74, 297 (1941).

    Article  CAS  Google Scholar 

  10. Mollison, P. L., and Polley, Margaret J., J. Immunol., 3, 11 (1960).

    CAS  Google Scholar 

  11. Becker, E. L., Fed. Proc., 18, 557 (1959).

    Google Scholar 

  12. Coombs, R. R. A., Blomfield, A. M., and Roberts, G. F., J. Hygiene, 48, 484 (1950).

    Article  CAS  Google Scholar 

  13. Mayer, M. M., Levine, L., Rapp, H. J., and Morncei, A. A., J. Immunol., 73, 443 (1954).

    CAS  PubMed  Google Scholar 

  14. Ellis, H. A., and Gell, P. G. H., Nature, 181, 1667 (1958).

    Article  ADS  CAS  Google Scholar 

  15. Matuhasi, T., and Usui, M., Med. and Biol., 46, 258 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Blood Transfusion Research Unit, Postgraduate Medical School of London, Ducane Road, London, W.12

    G. C. JENKINS, MARGARET J. POLLEY & P. L. MOLLISON

Authors
  1. G. C. JENKINS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MARGARET J. POLLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. L. MOLLISON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

JENKINS, G., POLLEY, M. & MOLLISON, P. Role of C′4 in the Antiglobulin Reaction. Nature 186, 482–483 (1960). https://doi.org/10.1038/186482a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/186482a0

  • Springer Nature Limited

This article is cited by

Search

Navigation