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Effect of Pituitary Growth Hormone in vivo on the Phosphorus/Oxygen Ratios of Isolated Rat Liver Mitochondria

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Abstract

RECENT reports tending to localize the site of action of thyroxine in uncoupling oxidative phosphorylation at the level of the mitochondrial membrane1,2 have served to emphasize the need for similar studies on possible sites of action of anterior pituitary growth hormone, a substance which produces generalized metabolic changes even more striking than those found with thyroxine. The present communication reports some results concerning the effect of the hormone on oxidative phosphorylation, using mitochondria isolated from the livers of normal rats or rats treated with growth hormone.

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Authors and Affiliations

  1. Institute of Ophthalmology, Judd Street, London, W.C.1

    C. N. GRAYMORE

  2. Department of Biochemistry, University College, London

    A. H. MELHUISH & A. L. GREENBAUM

Authors
  1. C. N. GRAYMORE
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  2. A. H. MELHUISH
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  3. A. L. GREENBAUM
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GRAYMORE, C., MELHUISH, A. & GREENBAUM, A. Effect of Pituitary Growth Hormone in vivo on the Phosphorus/Oxygen Ratios of Isolated Rat Liver Mitochondria. Nature 186, 392–393 (1960). https://doi.org/10.1038/186392b0

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