Skip to main content
SpringerLink
Log in

Flavins as Components of Folic Acid Reductases

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IT has been demonstrated that tetrahydrofolicacid is an important intermediate in the conversion of folic acid into the functional form of this vitamin1–3. This conversion has been shown to take place in two steps both of which require reduced triphosphopyridine nucleotide as the hydrogen carrier4. The following mechanism has been formulated:

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Greenberg, G. R., J. Amer. Chem. Soc., 76, 1458 (1954).

    Article  CAS  Google Scholar 

  2. Silverman, M., Keresztesy, J. C., Koval, G. J., and Gardiner, R. C., J. Biol. Chem., 226, 83 (1957).

    CAS  PubMed  Google Scholar 

  3. Blakley, R. L., Biochem. J., 58, 448 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Futterman, S., J. Biol. Chem., 228, 1031 (1957).

    CAS  PubMed  Google Scholar 

  5. Bratton, A. C., and Marshall, E. K., J. Biol. Chem., 128, 537 (1939).

    CAS  Google Scholar 

  6. Kenkare, U. W., and Braganca, B. M. (in preparation).

  7. Mueller, G. C., and Miller, J. A., J. Biol. Chem., 185, 145 (1950).

    CAS  PubMed  Google Scholar 

  8. Mahler, H. R., in Colowick, S. P., and Kaplan, N. O., ‘Methods in Enzymology’, 688 (Academic Press, New York, 1955).

    Google Scholar 

  9. Wadkins, C. L., and Mills, R. C., Fed. Proc., 15, 377 (1956).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Enzyme Chemistry Department, Indian Cancer Research Centre, Parel, Bombay, 12

    BEATRIZ M. BRAGANCA & U. W. KENKARE

Authors
  1. BEATRIZ M. BRAGANCA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. W. KENKARE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRAGANCA, B., KENKARE, U. Flavins as Components of Folic Acid Reductases. Nature 184, 1488–1489 (1959). https://doi.org/10.1038/1841488a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1841488a0

  • Springer Nature Limited

Search

Navigation