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Leucocytosis in Response to Bacteræmia as a Feature of the Acute Radiation Syndrome in the Plaice

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Abstract

BACTERIAL invasion of the blood-stream is a marked feature of the acute radiation syndrome in the mammal following exposure to mid-lethal and supra-lethal doses of ionizing radiation1–6. It is generally considered that the bacteria are enteric in origin and that they gain access to the blood-stream through failure of the host defence mechanism, following the radiation insult, that is, ulceration of the gastro-intestinal tract, and leucopænia1,7. According to Bennett et al. 3 death attributable to such infection of the blood-stream in dogs is always associated with leucopænia, and Cronkite and Brecher6 consider that the body of evidence available appears to establish a firm correlation between granulocytopænia and susceptibility to infection in radiation injury.

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References

  1. Prosser, C. L., Radiol., 49, 299 (1947).

    Article  CAS  Google Scholar 

  2. Miller, C. P., Hammond, C. W., and Tompkins, M. J., J. Lab. and Clin. Med., 38, 331 (1951).

    CAS  Google Scholar 

  3. Bennett, L. R., Rekens, P. E., Kresge, M., and Howland, J. W., University of Rochester Report, 76 (1949).

  4. Silverman, M. S., Bond, V. P., Greenman, V., and Chin, P. H., Rad. Res., 7 (1957).

  5. Hammond, C. W., Tompkins, M., and Miller, C. P., J. Exp. Med., 99, 405 (1954).

    Article  CAS  Google Scholar 

  6. Cronkite, E. P., and Brecher, G., Ann. N.Y. Acad. Sci., 59, 815 (1955).

    Article  ADS  CAS  Google Scholar 

  7. Perkins, E. H., Donaldsons, D. M., and Marcus, S., J. Immunol., 76, 169 (1956).

    CAS  PubMed  Google Scholar 

  8. Stearner, S. P., J. Exp. Zool., 115, 251 (1950).

    Article  Google Scholar 

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PRESTON, A. Leucocytosis in Response to Bacteræmia as a Feature of the Acute Radiation Syndrome in the Plaice. Nature 183, 832–833 (1959). https://doi.org/10.1038/183832b0

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