Abstract
THE diabetic syndromes observed in experimental animals and in man are due to metabolic abnormalities induced directly or indirectly by insulin deficiency and to lesions which affect tissues other than the β-cells of the islets of Langerhans. It is difficult to attribute the pathological effects observed in these syndromes to specific lesions since the methods at present available do not render animals rapidly and reversibly insulin-deficient without provoking other complicating effects.
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WRIGHT, P. Production of Acute Insulin Deficiency by Administration of Insulin Antiserum. Nature 183, 829–830 (1959). https://doi.org/10.1038/183829b0
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DOI: https://doi.org/10.1038/183829b0
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