Abstract
FOR a number of years we have been interested in the neuromuscular blocking properties of bis-onium compounds derived from substituted tropane nuclei, in which linking of the quaternary nitrogens was effected by a polymethylene or aralkyl chain. We observed that such compounds produced a flaccid paralysis on injection into chicks but tended to be long acting. This observation led to the preparation of a series of similar compounds (Fig. 1) in which the linking chain contained two ester-groupings as in suxamethonium. The latter is known to produce short-acting block which is, however, of depolarizing character.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAINING, C., JOHNSTON, R. & SMITH, J. Neuromuscular Blocking Agents of Short Duration. Nature 183, 542–543 (1959). https://doi.org/10.1038/183542a0
Issue Date:
DOI: https://doi.org/10.1038/183542a0
- Springer Nature Limited
This article is cited by
-
The changing pattern of neuromuscular block
Canadian Anaesthetists’ Society Journal (1961)