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Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations

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Abstract

THE work reported here stemmed from the experiments described in an earlier communication1 on p-aminobenzylpenicillin, in which discrepancies were observed between chemical and biological methods of penicillin assay when a precursor was omitted from penicillin fermentations.

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References

  1. Ballio, A., Chain, E. B., Dentice di Accadia, F., Rolinson, G. N., and Batchelor, F. R., Nature, 183, 180 (1959).

    Article  ADS  CAS  Google Scholar 

  2. Sheehan, J. C., Henery-Logan, K. R., and Johnson, D. A., J. Amer. Chem. Soc., 75, 3292 (1953).

    Article  CAS  Google Scholar 

  3. “The Chemistry of Penicillin”, 481 (Princeton University Press, 1949).

  4. Szabo, J. L., and Bruce, W. F., U.S. Patent 2,627,491; Chem. Abst., 48, 734 (1954).

    Google Scholar 

  5. Hockenhull, D. J. D., Ramachandran, K., and Walker, T. K., Arch. Biochem., 23, 160 (1949). Burger, A., “Medicinal Chemistry”, 2, 880 (Interscience Pub., 1951). Kato, T., Kagaku (Science), 23, 217 (1953); J. Antibiotics (Japan), 6, A, 130, 184 (1953). Abraham, E. P., Giornale di Microbiologica, 2, 102 (1956). Arnstein, H. R. V., and Crawhall, J. C., Biochem. J., 67, 180 (1957).

    Google Scholar 

  6. Sakaguchi, K., and Murao, S., J. Agric. Chem. Soc. Japan, 23, 411 (1950). Murao, S., Nippon Nogei-kagaku Kaishi, 29, 400, 404 (1955).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Beecham Research Laboratories, Ltd., Brockham Park, Betchworth, Surrey

    F. R. BATCHELOR, F. P. DOYLE, J. H. C. NAYLER & G. N. ROLINSON

Authors
  1. F. R. BATCHELOR
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  2. F. P. DOYLE
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  3. J. H. C. NAYLER
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  4. G. N. ROLINSON
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BATCHELOR, F., DOYLE, F., NAYLER, J. et al. Synthesis of Penicillin: 6-Aminopenicillanic Acid in Penicillin Fermentations. Nature 183, 257–258 (1959). https://doi.org/10.1038/183257b0

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