Abstract
IT is now established that the mast cells are an important source of histamine in the body1. Histamine can be released from these cells in vivo by the injection of certain substances, such as compound 48/802 and distilled water3, but the mechanism of its release in pathological conditions, such as anaphylaxis and tissue injury, has not yet been satisfactorily explained. This problem has been investigated by exposing isolated mast cells from the rat to tissue extracts. It was found that injured nucleated cells produce a factor which liberates histamine from mast cells with histological changes in the mast cells varying from cellular swelling to cellular disintegration.
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References
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Lowry, O. H., Graham, Helen T., Harris, Frances B., Priebat, Martha K., Marks, A. R., and Bregman, R. U., J. Pharmacol. and Exp. Therap., 112, 116 (1954).
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ARCHER, G. Release of Histamine from Mast Cells by Tissue Extracts. Nature 182, 726–727 (1958). https://doi.org/10.1038/182726a0
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DOI: https://doi.org/10.1038/182726a0
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