Skip to main content
SpringerLink
Log in

Cytolipin H, a Pure Lipid Hapten isolated from Human Carcinoma

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

ANTISERA prepared by injecting rabbits with cytoplasmic fractions or homogenates of human tissues frequently contain antibodies directed against substances extractable from the tissue with organic solvents and presumably lipid in nature. Material derived from tumours is reported to be more effective than that from normal tissues in eliciting this type of antibody1, suggesting that tumours may contain larger quantities of one or several lipoprotein antigens or possibly antigens qualitatively different. Exploration of this problem by the methods of immunochemical analysis is obstructed by several complications: the antigenic complexity of lipid extracts, the multiplicity of antibodies in the antiserum reagents, and the paucity of information regarding non-specific lipid–protein interactions for many classes of lipids. A fourth complication is of even greater moment than the other three combined, namely, the fact that specific lipid–protein interactions are markedly influenced by certain ubiquitous, non-specific lipids2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Witebsky, E., Klin. Wochenschr., 9, 58 (1930).

    Article  Google Scholar 

  2. Rapport, M. M., Alonzo, N. F., Graf, L., and Skipski, V. P., Cancer (in the press).

  3. Folch, J., Ascoli, I., Lees, M., Meath, J. A., and LeBaron, F. N., J. Biol. Chem., 191, 833 (1951).

    CAS  Google Scholar 

  4. Rapport, M. M., and Alonzo, N. F., “Biochemical Problems of Lipids”, edit. by Popjak, G., and LeBetron, E., 69 (Butterworth and Co., Ltd., 1956).

    Google Scholar 

  5. Rapport, M. M., Graf, L., and Alonzo, N. F., Cancer (in the press).

  6. Timell, T. E., Glaudemans, C. P. J., and Currie, A. L., Anal. Chem., 28, 1916 (1956).

    Article  CAS  Google Scholar 

  7. Radin, N. S., Brown, J. R., and Lavin, F. B., J. Biol. Chem., 219, 977 (1956).

    CAS  PubMed  Google Scholar 

  8. Isherwood, F. A., and Jermyn, M. A., Biochem. J., 44, 402 (1949).

    Article  Google Scholar 

  9. Rapport, M. M., and Graf, L., Ann. N.Y. Acad. Sci., 69, 608 (1957).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Laboratories and Research, New York State Department of Health, and Division of Experimental Pathology, Sloan–Kettering Institute for Cancer Research, New York

    MAURICE M. RAPPORT, LISELOTTE GRAF, VLADIMIR P. SKIPSKI & NICHOLAS F. ALONZO

Authors
  1. MAURICE M. RAPPORT
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LISELOTTE GRAF
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. VLADIMIR P. SKIPSKI
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. NICHOLAS F. ALONZO
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RAPPORT, M., GRAF, L., SKIPSKI, V. et al. Cytolipin H, a Pure Lipid Hapten isolated from Human Carcinoma. Nature 181, 1803–1804 (1958). https://doi.org/10.1038/1811803a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1811803a0

  • Springer Nature Limited

This article is cited by

Search

Navigation