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Isolation of an Erythropoietic Fraction from the Plasma of Rabbits made severely Anæmic with Phenylhydrazine

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Abstract

THE plasma of rabbits made severely anæmic with phenylhydrazine, with less than 3.7 gm. hæmoglobin per 100 ml. of blood, contains erythropoietic material. The erythropoietic activity has been demonstrated in heterologous species, for example, rats1, mice2 and dogs3, in the filtrate obtained after boiling the anæmic rabbit plasma at pH 5.5 for a few minutes.

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References

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Authors and Affiliations

  1. Kerckhoff Biological Laboratories, California Institute of Technology, Pasadena

    PETER H. LOWY, GEOFFREY KEIGHLEY & HENRY BORSOOK

  2. U.S. Naval School of Aviation Medicine, Pensacola, Florida

    ASHTON GRAYBIEL

Authors
  1. PETER H. LOWY
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  2. GEOFFREY KEIGHLEY
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  3. HENRY BORSOOK
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  4. ASHTON GRAYBIEL
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LOWY, P., KEIGHLEY, G., BORSOOK, H. et al. Isolation of an Erythropoietic Fraction from the Plasma of Rabbits made severely Anæmic with Phenylhydrazine. Nature 181, 1802–1803 (1958). https://doi.org/10.1038/1811802a0

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