Skip to main content
SpringerLink
Log in

Heparin and Christmas Factor

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

HEPARIN has been shown to combine with Chargaff's1 lung thromboplastin, which contains phospholipid. It inhibits the formation of intrinsic plasma thromboplastin2, and Douglas3 has shown that it must inhibit blood coagulation at an early stage. Heparin is also known4 to combine specifically with the β-lipoproteins of plasma or serum and to depress the plasma β-lipoprotein concentration when injected in vivo. Christmas factor has been shown to be present in a crude α- and β-globulin fraction of plasma5 and it may contain phospholipid6.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chargaff, E., Ziff, M., and Cohen, S. S., J. Biol. Chem., 136, 257 (1940).

    CAS  Google Scholar 

  2. MacMillan, R. L., and Brown, K. W. G., J. Lab. Clin. Med., 44, 378 (1954).

    CAS  PubMed  Google Scholar 

  3. Douglas, A. S., J. Clin. Invest., 35, 533 (1956).

    Article  CAS  Google Scholar 

  4. Burstein, M. Samaille, C.R. Acad. Sci., Paris, 243, 2185 (1956).

    CAS  Google Scholar 

  5. Biggs, R., Douglas, A. S., Macfarlane, R. R., Dacie, J. V., Pitney, W. R., Merskey, C., and O'Brien, J. R., Brit. Med. J., ii, 1378 (1952).

  6. O'Brien, J. R., Brit. J. Haematol., 2, 430 (1956).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Central Laboratory, Milton Road, Portsmouth, Hampshire

    J. R. O'BRIEN

Authors
  1. J. R. O'BRIEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'BRIEN, J. Heparin and Christmas Factor. Nature 181, 1801–1802 (1958). https://doi.org/10.1038/1811801b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1811801b0

  • Springer Nature Limited

This article is cited by

Search

Navigation