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Effects of 8-Azaguanine on the Synthesis of Protein and Nucleic Acids in Bacillus cereus

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Abstract

THE guanine analogue, 8-azaguanine, inhibits growth of a variety of tissues and micro-organisms, possibly as a result of its incorporation into ribo-nucleic acids. In Bacillus cereus, as much as 40 per cent of the ribonucleic acid guanine has been shown to be replaced by azaguanine1. The inhibition of growth of these bacteria (as estimated from optical density measurements) conceals more complex changes of metabolism, especially a dissociation of the formation of ribonucleic acid from that of protein2. These changes have now been more thoroughly studied, and the essential observations are the subject of this communication.

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References

  1. Smith, J. D., and Matthews, R. E., Biochem. J., 66, 323 (1957).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chantrenne, H., Rec. Trav. Chim. Pays-Bos (in the press).

  3. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  4. Gros, F., and Gros, F., Exp. Cell Res., 14, 104 (1958).

    Article  CAS  PubMed  Google Scholar 

  5. Neidhardt, F. C., and Gros, F., Biochim. Biophys. Acta, 25, 513 (1957).

    Article  CAS  PubMed  Google Scholar 

  6. Mandel, H. G., J. Biol. Chem., 225, 137 (1957).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Chimie biologique, Faculté des Sciences, Université de Bruxelles,

    H. CHANTRENNE & S. DEVREUX

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  1. H. CHANTRENNE
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  2. S. DEVREUX
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CHANTRENNE, H., DEVREUX, S. Effects of 8-Azaguanine on the Synthesis of Protein and Nucleic Acids in Bacillus cereus . Nature 181, 1737–1738 (1958). https://doi.org/10.1038/1811737a0

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