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Immunological Estimation of a Component of Complement

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Abstract

COMPLEMENT is normally estimated by the hæmolytic method, for which at least four components must be present: whichever is present in least relative amount controls the ‘titre’. A simple method for estimating some or all of these components separately would be of value, particularly in clinical investigations. An immuno-diffusion method in agar1 has been applied to the semi-quantitative estimation of one of these, probably C′ 1, in human sera.

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References

  1. Gell, P. G. H., J. Clin. Path., 8, 269 (1955).

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  2. Pillemer, L., Seifter, S., San Clemente, C. L., and Ecker, E. E., J. Immunol., 47, 205 (1943).

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Authors and Affiliations

  1. Department of Experimental Pathology, University of Birmingham,

    H. A. ELLIS & P. G. H. GELL

Authors
  1. H. A. ELLIS
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  2. P. G. H. GELL
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ELLIS, H., GELL, P. Immunological Estimation of a Component of Complement. Nature 181, 1667–1668 (1958). https://doi.org/10.1038/1811667a0

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