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Free Radical produced in the Reaction of Metmyoglobin with Hydrogen Peroxide

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Abstract

IN a previous communication1, it was reported that a free radical is formed during the action of hydrogen peroxide on methæmoglobin. As its g-value approximated to that of a free electron, this result was interpreted in terms of electron removal from the π-orbitals of the porphyrin ring, by analogy with the reactions occurring during the oxidation of porphyrins and phthalocyanines2. This explanation, involving the postulate of little interaction between unpaired electron and central iron atom, conflicted with the results of titration studies3, and the evidence from paramagnetic susceptibility4.

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References

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Authors and Affiliations

  1. Department of Electronics, University of Southampton,

    J. F. GIBSON & D. J. E. INGRAM

  2. Molteno Institute, University of Cambridge,

    P. NICHOLLS

Authors
  1. J. F. GIBSON
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  2. D. J. E. INGRAM
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  3. P. NICHOLLS
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GIBSON, J., INGRAM, D. & NICHOLLS, P. Free Radical produced in the Reaction of Metmyoglobin with Hydrogen Peroxide. Nature 181, 1398–1399 (1958). https://doi.org/10.1038/1811398a0

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