Skip to main content
SpringerLink
Log in

Enzymic Synthesis of Nitrogen-containing Disaccharides by α-Galactosyl Transfer

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

SEROLOGICAL and enzymic inhibition tests with simple sugars and oligosaccharides of known structure have in recent years given valuable indications about the sugars which are most important for specificity in the complex mucopolysaccharide materials possessing blood-group activity1. Di-and tri-saccharides of known structure which are composed of the sugars present in the blood-group substances are required in order to extend these observations; the enzymic syntheses of two such disaccharides which have not previously been described, α-D-galactosyl-(1→6)-N-acetyl-D-glucosamine (1) and α-D-galactosyl-(1→6) - N -acetyl-D-gal-actosamine (2), are reported here.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Watkins, W. M., and Morgan, W. T. J., Nature, 169, 825 (1952). Morgan, W. T. J., and Watkins, W. M., Brit. J. Exp. Path., 34, 94 (1953). Kabat, E. A., and Leskowitz, S., J. Amer. Chem. Soc., 77, 5159 (1955). Watkins, W. M., and Morgan, W. T. J., Nature, 175, 676 (1955); 178, 1289 (1956). Côté, R., and Morgan, W. T. J., ibid., 178, 1171 (1956).

    Article  ADS  CAS  Google Scholar 

  2. Zillikin, F., Smith, P. N., Rose, C. S., György, P., J. Biol. Chem., 208, 299 (1954). Alessandrini, A., Schmidt, E., Zilliken, F., and György, P., J. Biol. Chem., 220, 71 (1956).

    Google Scholar 

  3. Wallenfels, K., Ann. Chem., 579, 113 (1952). Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 88, 1713 (1955).

    Article  Google Scholar 

  4. Watkins, W. M., Biochem. J., 54, xxxiii (1953), and unpublished observations.

    Google Scholar 

  5. Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 88, 1713 (1955).

    Article  CAS  Google Scholar 

  6. Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 87, 1553 (1954).

    Article  CAS  Google Scholar 

  7. Zilliken, F., Smith, P. N., Tomarelli, R. M., and György, P., Arch. Biochem. Biophys., 54, 398 (1955).

    Article  CAS  Google Scholar 

  8. Bacon, J. S. D., and Edelman, J., Biochem. J., 48, 114 (1951).

    Article  CAS  Google Scholar 

  9. Partridge, S. M., and Westall, R. G., Biochem. J., 42, 238 (1948).

    Article  CAS  Google Scholar 

  10. Jeanloz, R. W., and Trémège, M., Fed. Proc., 15, 282 (1954).

    Google Scholar 

  11. Kuhn, R., Gauhe, A., and Baer, H. H., Chem. Ber., 87, 1138 (1954).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lister Institute of Preventive Medicine, Chelsea Bridge Road, London, S.W.1.

    WINIFRED M. WATKINS

Authors
  1. WINIFRED M. WATKINS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WATKINS, W. Enzymic Synthesis of Nitrogen-containing Disaccharides by α-Galactosyl Transfer. Nature 181, 117–118 (1958). https://doi.org/10.1038/181117a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/181117a0

  • Springer Nature Limited

This article is cited by

Search

Navigation