Abstract
SEVERAL reports have indicated that murexine (β-imidazolyl-4-(5)acrylcholine) has strong nicotinic and curare-like actions but shows little or no muscarinic action1–4. Recent work in our laboratories5 suggests that murexine and two related esters, imidazolepropionylcholine and imidazoleacetylcholine, have significant cholinomimetic (muscarinic) activity on the vascular system of the intact dog. When injected intra-arterially in anæsthetized dogs, murexine and the two esters produced a local vasodilatation which was blocked by atropine but not by hexamethonium.
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References
Erspamer, V., and Glässer, A., Brit. J. Pharmacol., 12, 176 (1957).
Erspamer, V., Experientia, 4, 226 (1948).
Kewitz, H., Arch. Exp. Path. u. Pharmakol., 225, 111 (1955).
Conroy, C., Kappel, B., Ferruggia, T., and Randall, L. O., Fed. Proc., 15, 412 (1956).
Winbury, M. M., Wolf, J. K., and Tabachnick, I. I. A., Fed. Proc., 16, 347 (1957); J. Pharmacol. (in the press).
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WINBURY, M. Muscarinic Action of Murexine and Some Related Choline Esters. Nature 180, 988–989 (1957). https://doi.org/10.1038/180988a0
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DOI: https://doi.org/10.1038/180988a0
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