Abstract
IN the course of a study on the protection of mice against a lethal dose of X-rays, it was found in this laboratory that the administration of homologous or heterologous (rat) bone marrow after the irradiation may result in a significant reduction of mortality. In the animals surviving after heterologous therapy the circulating erythrocytes were agglutinated by anti-rat serum ; furthermore, the granulocytes showed an alkaline phosphatase reaction which is specific for rat white cells. These results proved that a transplantation of rat hæmatopoietic tissue had been achieved1.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Vos, O., Davids, J. A. G., Weyzen, W. W. H., and van Bekkum, D. W., Acta Physiol. Pharmacol. Neerl., 4, 482 (1956).
Makinodan, T., Proc. Soc. Exp. Biol. Med., 92, 174 (1956).
Scheidegger, J. J., Int. Arch. Allergy and Appl. Immunol., 7, 103 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WEYZEN, W., Vos, O. Production of Rat Serum Proteins in Irradiated Mice. Nature 180, 288–289 (1957). https://doi.org/10.1038/180288b0
Issue Date:
DOI: https://doi.org/10.1038/180288b0
- Springer Nature Limited
This article is cited by
-
Zum Mechanismus einer heterologen, cutanen Graft-Versus-Host-Reaktion in der Maus
Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie (1969)
-
Antibody Formation and Experimentally Induced Chimerism in Very Young Rabbits
Nature (1966)
-
Serum Protein Formation of Donor Type in Rat-Into-Mouse Chimaeras
Nature (1965)
-
Presence of Donor Specific Gamma-Globulins in Sera of Allogeneic Mouse Radiation Chimeras
Nature (1964)
-
Concerning the appearance of incomplete antibodies following bone marrow transplantation under conditions of radiation sickness
Bulletin of Experimental Biology and Medicine (1962)