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Surviving Rat Skin Grafts in Mice

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Abstract

UNTIL recently, orthotopic transplantation of heterologous normal tissue could not be achieved in mammals. In 1956 it was demonstrated independently by Nowell et al. 1, Ford et al. 2 and Vos et al. 3 that a persistent proliferation of rat hæmatopoietic cells occurs in mice which survive a lethal total body dose of X-rays as the result of the administration of rat bone-marrow. More than one year after the transplantation in some of these mice all the erythrocytes and granulocytes were found to be of rat origin4.

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References

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Authors and Affiliations

  1. Medical Biological Laboratory of the National Defence Research Council, 139 Lange Kleiweg, Rijswijk-Z.H., The Netherlands

    O. BROCADES ZAALBERG, O. Vos & D. W. VAN BEKKUM

Authors
  1. O. BROCADES ZAALBERG
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  2. O. Vos
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  3. D. W. VAN BEKKUM
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ZAALBERG, O., Vos, O. & VAN BEKKUM, D. Surviving Rat Skin Grafts in Mice. Nature 180, 238–239 (1957). https://doi.org/10.1038/180238b0

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