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Site of Reduction of Nitrofurazone by Bacteria

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Abstract

ANTIBACTERIAL, nitrofurans are reduced to the corresponding amino-compounds by Aerobacter aerogenes 1. The site of the reaction (in a different organism) is now shown to be the cytoplasmic membrane rather than the cell wall or cytoplasm. Lack of an enzyme system capable of effecting this reaction in the bacterial cell walls was not unexpected2.

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References

  1. Beckett and Robinson, Chem. and Ind., 523 (1957); and unpublished data.

  2. Weibull, Symp. Soc. Gen. Microbiol., 6, 123 (1956). McQuillen, ibid., 6, 127 (1956).

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  3. Weibull, J. Bact., 66, 688 (1953).

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  4. McQuillen, Symp. Soc. Gen. Microbiol., 6, 145 (1956).

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  5. Salton and Horne, Biochim. et Biophys. Acta, 7, 177 (1951).

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Authors and Affiliations

  1. Chelsea School of Pharmacy, Chelsea College of Science and Technology, Manresa Road, London, S.W.3.

    A. H. BECKETT & ANN E. ROBINSON

Authors
  1. A. H. BECKETT
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  2. ANN E. ROBINSON
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BECKETT, A., ROBINSON, A. Site of Reduction of Nitrofurazone by Bacteria. Nature 180, 1206–1207 (1957). https://doi.org/10.1038/1801206a0

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