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Structure of a New Pyridine Nucleotide isolated from Penicillium chrysogenum

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Abstract

IN the course of a study of the acid-soluble nucleotides occurring in the mycelium of Penicillium chrysogenum 1 we isolated a compound having a typical adenosine ultra-violet spectrum, and showing the appearance of a peak at 315 mµ on addition of potassium cyanide. This compound could be distinguished from diphosphopyridine nucleotide and triphosphopyridine nucleotide not only by its inability to act as a coenzyme for alcohol dehydrogenase and for glucose-6-phosphate dehydrogenase but also by the fact that it was eluted by formic acid from a ‘Dowex-1’ (formate) column behind diphosphopyridine nucleotide and before triphosphopyridine nucleotide.

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Authors and Affiliations

  1. Istituto Superiore di Sanità, International Centre for Microbiological Chemistry, Rome

    GIOVANNI SERLUPI-CRESCENZI & ALESSANDRO BALLIO

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  1. GIOVANNI SERLUPI-CRESCENZI
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  2. ALESSANDRO BALLIO
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SERLUPI-CRESCENZI, G., BALLIO, A. Structure of a New Pyridine Nucleotide isolated from Penicillium chrysogenum . Nature 180, 1203–1204 (1957). https://doi.org/10.1038/1801203a0

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