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Coagulant Action of Proteolytic Enzymes

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Abstract

Eagle and Harris1 demonstrated that the coagulant actions of papain and trypsin differ. Trypsin acts by converting prothrombin to thrombin: papain clots fibrinogen directly. The thrombin-like action of papain on fibrinogen has been ascribed to its proteolytic property2,3. Light-scattering studies on the papain–fibrinogen reaction4 have shown that the extent of polymerization of fibrinogen is roughly of the same order as in the thrombin–fibrinogen reaction.

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Authors and Affiliations

  1. Dept. of Pathology (Hæmatology), Postgraduate Medical School, University of London, London, W.12.

    HERBERT M. RUBINSTEIN

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  1. HERBERT M. RUBINSTEIN
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RUBINSTEIN, H. Coagulant Action of Proteolytic Enzymes. Nature 180, 1202–1203 (1957). https://doi.org/10.1038/1801202a0

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