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Effect of Inorganic Complex Ions on Transmission at a Neuromuscular Junction

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Abstract

SOME aspects of the chemical and biological activity of the inorganic complex ions have been previously reported by Beccari1 and by Dwyer and co-workers2–4. These workers have indicated that the complex cations show extremely high chemical stability, and most probably pass through the body unchanged. They also exhibit marked biological activity4, and when injected intraperitoneally into mice2 cause paralysis and death by respiratory failure suggestive of curariform activity. We have investigated their pharmacological mode of action on the rat diaphragm–phrenic nerve and toad (Bufo marinus) rectus abdominis muscle preparations. Investigations have also been carried out, in collaboration with Dr. Rosamond M. Eccles, of the Department of Physiology, Australian National University, using the toad sartorius nerve–muscle preparation and the isolated superior cervical ganglion of the rabbit.

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References

  1. Beccari, E., Boll. soc. ital. biol. sper., 13, 6 and 8 (1938) 16, 214 and 216 (1941); Arch. sci. biol. (Italy), 27, 204 (1941); Arch. sci. Physiol., 3, 611 (1949).

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Authors and Affiliations

  1. Dept. of Chemistry, University of Sydney, N.S.W.

    F. P. DWYER & ELEANORA C. GYARFAS

  2. Dept. of Physiology, University of Melbourne, Victoria

    R. D. WRIGHT & A. SHULMAN

Authors
  1. F. P. DWYER
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  2. ELEANORA C. GYARFAS
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  3. R. D. WRIGHT
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  4. A. SHULMAN
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DWYER, F., GYARFAS, E., WRIGHT, R. et al. Effect of Inorganic Complex Ions on Transmission at a Neuromuscular Junction. Nature 179, 425–426 (1957). https://doi.org/10.1038/179425a0

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