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Incorporation of Adenine and Uracil into Ribonucleic Acid during Enzyme Induction in Resting Yeast

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Abstract

Spiegelman et al. 1, Pardee2 and Creaser3 have shown that purine or pyrimidine analogues inhibit induced enzyme formation in various micro-organisms. This strongly suggests that synthesis of nucleic acid is necessary for the formation of adaptive enzymes. Gale and Folkes4 have shown that incorporation of uracil into ribonucleic acid is increased during induced formation of galactosidase in disrupted Staphylococcus.

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References

  1. Spiegelman, S., Halvorson, H. O., and Ben-Ishai, R., in “A Symposium on Amino Acid Metabolism” (Baltimore, 1955).

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  2. Pardee, A. B., J. Bact., 69, 233 (1955).

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  3. Creaser, E. H., Nature, 175, 899 (1955); 176, 556 (1955).

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  4. Gale, E. F., and Folkes, J. P., Biochem. J., 50, 675 (1955).

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Authors and Affiliations

  1. Laboratoire de Chimie biologique, Faculté des Sciences, Université de Bruxelles,

    H. CHANTRENNE

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  1. H. CHANTRENNE
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CHANTRENNE, H. Incorporation of Adenine and Uracil into Ribonucleic Acid during Enzyme Induction in Resting Yeast. Nature 177, 579–580 (1956). https://doi.org/10.1038/177579a0

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