Abstract
ANTI-COMPETITIVE (uncompetitive) inhibition, in which the inhibitor combines with the enzyme-substrate complex but not with the enzyme, has been considered theoretically by Burk in Ebersole, Guttentag and Wilson1.
Similar content being viewed by others
References
Burk, D., quoted by Ebersole, E. R., Guttentag, C., and Wilson, P. W., Arch. Biochem., 3, 399 (1944).
Friedenwald, J. S., and Maengwyn-Davies, G. D., “The Mechanism of Enzyme Action”, 164 (The Johns Hopkins Press, Baltimore, 1954).
Winzler, R. J., J. Cellular Comp. Physiol., 21, 229 (1943).
Schales, O., Suthon, A. M., Roux, R. M., Lloyd, E., and Schales, S. S., Arch. Biochem., 19, 119 (1948).
Dodgson, K. S., Spencer, B., and Williams, K., Biochem. J., [61, 374 (1955)].
Rosenfeld, L. E., and Ruchelman, A. A., Ukr. Biochem. J., 16, 53 (1940).
Dzialoszynski, L. M., Nature, 166, 157 (1950).
Robinson, D., Smith, J. N., Spencer, B., and Williams, R. T., Biochem. J., 51, 202 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DODGSON, K., SPENCER, B. & WILLIAMS, K. Examples of Anti-competitive Inhibition. Nature 177, 432–433 (1956). https://doi.org/10.1038/177432b0
Issue Date:
DOI: https://doi.org/10.1038/177432b0
- Springer Nature Limited
This article is cited by
-
The inhibitory effect of homologous immunoglobulin G on the degradation of antigen (human serum albumin) by rabbit cathepsin D
Folia Microbiologica (1969)
-
Amylolytic enzymes ofEndomycopsis capsularis
Folia Microbiologica (1966)